Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA

RbpA and CarD are essential transcription regulators in mycobacteria. Mechanistic analyses of promoter open complex (RPo) formation establish that RbpA and CarD cooperatively stimulate formation of an intermediate (RP2) leading to RPo; formation of RP2 is likely a bottleneck step at the majority of...

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Pubblicato in:eLife
Autori principali: Hubin, Elizabeth A, Fay, Allison, Xu, Catherine, Bean, James M, Saecker, Ruth M, Glickman, Michael S, Darst, Seth A, Campbell, Elizabeth A
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Biochemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302886/
https://ncbi.nlm.nih.gov/pubmed/28067618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22520
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