Editor’s Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway

Hepatotoxicity is of major concern for humans exposed to industrial chemicals and drugs. Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism, enhanced the sensitivity to liver injury in mice after toxicant exposure, but the precise mechanism remains unclear. In...

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Vydáno v:Toxicol Sci
Hlavní autoři: Takahashi, Shogo, Tanaka, Naoki, Golla, Srujana, Fukami, Tatsuki, Krausz, Kristopher W., Polunas, Marianne A., Weig, Blair C., Masuo, Yusuke, Xie, Cen, Jiang, Changtao, Gonzalez, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Farnesoid X Receptor and Carbon Tetrachloride-Induced Liver Injury
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837376/
https://ncbi.nlm.nih.gov/pubmed/28505368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx094
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