Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The development of tau imaging agents has enabled visualization of tau lesions in tauopathy patients, but the modes of their binding to different tau strai...

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Bibliografiske detaljer
Udgivet i:Brain
Main Authors: Ono, Maiko, Sahara, Naruhiko, Kumata, Katsushi, Ji, Bin, Ni, Ruiqing, Koga, Shunsuke, Dickson, Dennis W., Trojanowski, John Q., Lee, Virginia M-Y., Yoshida, Mari, Hozumi, Isao, Yoshiyama, Yasumasa, van Swieten, John C., Nordberg, Agneta, Suhara, Tetsuya, Zhang, Ming-Rong, Higuchi, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837223/
https://ncbi.nlm.nih.gov/pubmed/28087578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aww339
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