A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii

Acinetobacter baumannii ATCC 19606 can grow without lipooligosaccharide (LOS). Lack of LOS can result from disruption of the early lipid A biosynthetic pathway genes lpxA, lpxC or lpxD. Although LOS itself is not essential for growth of A. baumannii ATCC 19606, it was previously shown that depletion...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Richie, Daryl L., Wang, Lisha, Chan, Helen, De Pascale, Gianfranco, Six, David A., Wei, Jun-Rong, Dean, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837183/
https://ncbi.nlm.nih.gov/pubmed/29505586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193851
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