Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondria

Vms1 translocates to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mitochondrial protein homeostasis. Mitochondrial targeting of Vms1 is mediated by its conserved Mitochondrial Targeting Domain (MTD), which in unstressed conditions is inhibited by i...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Nielson, Jason. R., Fredrickson, Eric K., Waller, T. Cameron, Rendón, Olga Zurita, Schubert, Heidi L., Lin, Zhenjian, Hill, Christopher P., Rutter, Jared
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837041/
https://ncbi.nlm.nih.gov/pubmed/29149595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.022
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