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Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondria

Vms1 translocates to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mitochondrial protein homeostasis. Mitochondrial targeting of Vms1 is mediated by its conserved Mitochondrial Targeting Domain (MTD), which in unstressed conditions is inhibited by i...

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Vydáno v:Mol Cell
Hlavní autoři: Nielson, Jason. R., Fredrickson, Eric K., Waller, T. Cameron, Rendón, Olga Zurita, Schubert, Heidi L., Lin, Zhenjian, Hill, Christopher P., Rutter, Jared
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837041/
https://ncbi.nlm.nih.gov/pubmed/29149595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.022
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