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Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondria

Vms1 translocates to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mitochondrial protein homeostasis. Mitochondrial targeting of Vms1 is mediated by its conserved Mitochondrial Targeting Domain (MTD), which in unstressed conditions is inhibited by i...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Nielson, Jason. R., Fredrickson, Eric K., Waller, T. Cameron, Rendón, Olga Zurita, Schubert, Heidi L., Lin, Zhenjian, Hill, Christopher P., Rutter, Jared
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837041/
https://ncbi.nlm.nih.gov/pubmed/29149595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.022
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