Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

BACKGROUND: Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed that so...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:BMC Med Genomics
Hlavní autoři: Boyarskikh, Ulyana, Pintus, Sergey, Mandrik, Nikita, Stelmashenko, Daria, Kiselev, Ilya, Evshin, Ivan, Sharipov, Ruslan, Stegmaier, Philip, Kolpakov, Fedor, Filipenko, Maxim, Kel, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836833/
https://ncbi.nlm.nih.gov/pubmed/29504919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0330-5
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky