Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

BACKGROUND: Small molecule Nutlin-3 reactivates p53 in cancer cells by interacting with the complex between p53 and its repressor Mdm-2 and causing an increase in cancer cell apoptosis. Therefore, Nutlin-3 has potent anticancer properties. Clinical and experimental studies of Nutlin-3 showed that so...

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Detalles Bibliográficos
Publicado en:BMC Med Genomics
Main Authors: Boyarskikh, Ulyana, Pintus, Sergey, Mandrik, Nikita, Stelmashenko, Daria, Kiselev, Ilya, Evshin, Ivan, Sharipov, Ruslan, Stegmaier, Philip, Kolpakov, Fedor, Filipenko, Maxim, Kel, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836833/
https://ncbi.nlm.nih.gov/pubmed/29504919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0330-5
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