The transcriptionally permissive chromatin state of embryonic stem cells is acutely tuned to translational output

A permissive chromatin environment coupled to hypertranscription drives the rapid proliferation of embryonic stem cells (ESCs) and peri-implantation embryos. We carried out a genome-wide screen to systematically dissect the regulation of the euchromatic state of ESCs. The results revealed that cellu...

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Udgivet i:Cell Stem Cell
Main Authors: Bulut-Karslioglu, Aydan, Macrae, Trisha A., Oses-Prieto, Juan A., Covarrubias, Sergio, Percharde, Michelle, Ku, Gregory, Diaz, Aaron, McManus, Michael T., Burlingame, Alma L., Ramalho-Santos, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836508/
https://ncbi.nlm.nih.gov/pubmed/29499153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.02.004
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