Dual cyclooxygenase–fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

The cyclooxygenases COX-1 and COX-2 oxygenate arachidonic acid (AA) to prostaglandin H(2) (PGH(2)). COX-2 also oxygenates the endocannabinoids 2-arachidonoylglycerol (2-AG) and arachidonoylethanolamide (AEA) to the corresponding PGH(2) analogs. Both enzymes are targets of nonsteroidal anti-inflammat...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Goodman, Michael C., Rouzer, Carol A., Banerjee, Surajit, Ghebreselasie, Kebreab, Migliore, Marco, Piomelli, Daniele, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836124/
https://ncbi.nlm.nih.gov/pubmed/29326169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802058
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