S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer

Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood. Methods: Mass spectrometry analys...

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Pubblicato in:Theranostics
Autori principali: Huang, Yumei, Hu, Kaishun, Zhang, Sheng, Dong, Xiaorong, Yin, Zhongyuan, Meng, Rui, Zhao, Yingchao, Dai, Xiaofang, Zhang, Tao, Yang, Kunyu, Liu, Li, Huang, Kai, Shi, Shaojun, Zhang, Yu, Chen, Junjie, Wu, Gang, Xu, Shuangbing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835936/
https://ncbi.nlm.nih.gov/pubmed/29507620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.22552
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