BRCA1 through its E3 Ligase Activity Regulates the Transcription Factor Oct1 and Carbohydrate Metabolism

The tumor suppressor BRCA1 regulates the DNA damage response (DDR) and other processes that remain incompletely defined. Among these, BRCA1 heterodimerizes with BARD1 to ubiquitylate targets via its N-terminal E3 ligase activity. Here it is demonstrated that BRCA1 promotes oxidative metabolism by de...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Vázquez-Arreguín, Karina, Maddox, Jessica, Kang, Jinsuk, Park, Dongju, Cano, Reuben R., Factor, Rachel E., Ludwig, Thomas, Tantin, Dean
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835178/
https://ncbi.nlm.nih.gov/pubmed/29330289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0364
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