Oct1 Is a Switchable, Bipotential Stabilizer of Repressed and Inducible Transcriptional States

Little is known regarding how the Oct1 transcription factor regulates target gene expression. Using murine fibroblasts and two target genes, Polr2a and Ahcy, we show that Oct1 recruits the Jmjd1a/KDM3A lysine demethylase to catalyze the removal of the inhibitory histone H3K9 dimethyl mark and block...

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Bibliografiske detaljer
Main Authors: Shakya, Arvind, Kang, Jinsuk, Chumley, Jeffrey, Williams, Matthew A., Tantin, Dean
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013004/
https://ncbi.nlm.nih.gov/pubmed/21051540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.174045
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