Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatography-mass spectrometry (GC- or LC-MS) or biochemical detection. While these methods are highly...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Longuespée, Rémi, Wefers, Annika K., De Vita, Elena, Miller, Aubry K., Reuss, David E., Wick, Wolfgang, Herold-Mende, Christel, Kriegsmann, Mark, Schirmacher, Peter, von Deimling, Andreas, Pusch, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834865/
https://ncbi.nlm.nih.gov/pubmed/29499756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0523-3
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