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Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase

Apoptotic cells expose phosphatidylserine (PtdSer) on their cell surface and are recognized by macrophages for clearance. Xkr8 is a scramblase that exposes PtdSer in a caspase-dependent manner. Here, we found that among the three Xkr members with caspase-dependent scramblase activity, mouse hematopo...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kawano, Mahiru, Nagata, Shigekazu
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834722/
https://ncbi.nlm.nih.gov/pubmed/29440417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720732115
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