Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria

Growing evidence shows that generation of reactive oxygen species (ROS) derived from antibiotic-induced metabolic perturbation contribute to antibiotic lethality. However, our knowledge of the mechanisms by which antibiotic-induced oxidative stress actually kills cells remains elusive. Here, we show...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fan, Xiao-Yong, Tang, Bi-Kui, Xu, Yuan-Yuan, Han, Ang-Xuan, Shi, Kun-Xiong, Wu, Yong-Kai, Ye, Yu, Wei, Mei-li, Niu, Chen, Wong, Ka-Wing, Zhao, Guo-Ping, Lyu, Liang-Dong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834715/
https://ncbi.nlm.nih.gov/pubmed/29382762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719627115
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