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Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells
Trastuzumab emtansine (T-DM1) is an antibody drug conjugate (ADC) that was recently approved for the treatment of HER-2-positive metastatic breast cancer. The drug sensitivity of ADCs depends mainly on the internalization efficiency of the drug. Caveolin-1 was shown to promote T-DM1 internalization...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5834501/ https://ncbi.nlm.nih.gov/pubmed/29500444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22250-8 |
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