Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity

Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. Since KRAS mutations are the m...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Leung, Elaine Lai Han, Luo, Lian Xiang, Liu, Zhong Qiu, Wong, Vincent Kam Wai, Lu, Lin Lin, Xie, Ying, Zhang, Ni, Qu, Yuan Qing, Fan, Xing Xing, Li, Ying, Huang, Min, Xiao, Dai Kai, Huang, Jun, Zhou, Yan Ling, He, Jian Xing, Ding, Jian, Yao, Xiao Jun, Ward, David C., Liu, Liang
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833846/
https://ncbi.nlm.nih.gov/pubmed/29440631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0065-9
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires