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The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis

Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression e...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Gao, Yanpan, Ge, Wei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833786/
https://ncbi.nlm.nih.gov/pubmed/29348610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0040-5
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