A novel autophagy inhibitor berbamine blocks SNARE-mediated autophagosome-lysosome fusion through upregulation of BNIP3

Increasing evidences reveal that autophagy inhibitor could enhance the effect of chemotherapy to cancer. However, few autophagy inhibitors are currently approved for clinical application in humans. Berbamine (BBM) is a natural compound extracted from traditional Chinese medicine that is widely used...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Fu, Ruoqiu, Deng, Qin, Zhang, Hongwei, Hu, Xiaoye, Li, Yunong, Liu, Yanxia, Hu, Jinjiao, Luo, Qingsong, Zhang, Yanhao, Jiang, Xiuxing, Li, Lirong, Yang, Chong, Gao, Ning
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833711/
https://ncbi.nlm.nih.gov/pubmed/29445175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0276-8
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