Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na(+)/Ca(2+) exchanger 3 downregulation

Preconditioning (PC) is a phenomenon wherein a mild insult induces resistance to a later, severe injury. Although PC has been extensively studied in several neurological disorders, no studies have been performed in amyotrophic lateral sclerosis (ALS). Here we hypothesize that a sub-toxic acute expos...

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Udgivet i:Cell Death Dis
Main Authors: Anzilotti, Serenella, Brancaccio, Paola, Simeone, Giuseppe, Valsecchi, Valeria, Vinciguerra, Antonio, Secondo, Agnese, Petrozziello, Tiziana, Guida, Natascia, Sirabella, Rossana, Cuomo, Ornella, Cepparulo, Pasquale, Herchuelz, Andrè, Amoroso, Salvatore, Di Renzo, Gianfranco, Annunziato, Lucio, Pignataro, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833681/
https://ncbi.nlm.nih.gov/pubmed/29434186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0227-9
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