EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy

The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the crosstalk between these two pathways and its implications in targeted therapy remains unclear. We found that the activated EGFR signali...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Xia, Hongwei, Dai, Xinyu, Yu, Huangfei, Zhou, Sheng, Fan, Zhenghai, Wei, Guoqing, Tang, Qiulin, Gong, Qiyong, Bi, Feng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833379/
https://ncbi.nlm.nih.gov/pubmed/29449645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0302-x
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