Elongator and codon bias regulate protein levels in mammalian peripheral neurons

Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the translation of codon-biased genes in lower organisms. Here we investigate whether Elongator serves a similar function...

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Publicado no:Nat Commun
Main Authors: Goffena, Joy, Lefcort, Frances, Zhang, Yongqing, Lehrmann, Elin, Chaverra, Marta, Felig, Jehremy, Walters, Joseph, Buksch, Richard, Becker, Kevin G., George, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832791/
https://ncbi.nlm.nih.gov/pubmed/29497044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03221-z
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