Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3(+) progenitors and peripheral neurons

Familial dysautonomia (FD) is a devastating developmental and progressive peripheral neuropathy caused by a mutation in the gene inhibitor of kappa B kinase complex-associated protein (IKBKAP). To identify the cellular and molecular mechanisms that cause FD, we generated mice in which Ikbkap express...

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Main Authors: George, Lynn, Chaverra, Marta, Wolfe, Lindsey, Thorne, Julian, Close-Davis, Mattheson, Eibs, Amy, Riojas, Vickie, Grindeland, Andrea, Orr, Miranda, Carlson, George A., Lefcort, Frances
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831979/
https://ncbi.nlm.nih.gov/pubmed/24173031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308596110
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