De novo adipocyte differentiation from Pdgfrβ(+) preadipocytes protects against pathologic visceral adipose expansion in obesity

Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling are largely unknown. Here, we test the hypothesis that the potential to recruit new adipocytes from Pdgfrβ(+) p...

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Udgivet i:Nat Commun
Main Authors: Shao, Mengle, Vishvanath, Lavanya, Busbuso, Napoleon C., Hepler, Chelsea, Shan, Bo, Sharma, Ankit X., Chen, Shiuhwei, Yu, Xinxin, An, Yu A., Zhu, Yi, Holland, William L., Gupta, Rana K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832777/
https://ncbi.nlm.nih.gov/pubmed/29497032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03196-x
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