Adenovirus-Mediated Delivery of Decoy Hyper Binding Sites Targeting Oncogenic HMGA1 Reduces Pancreatic and Liver Cancer Cell Viability

High mobility group AT-hook 1 (HMGA1) protein is an oncogenic architectural transcription factor that plays an essential role in early development, but it is also implicated in many human cancers. Elevated levels of HMGA1 in cancer cells cause misregulation of gene expression and are associated with...

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Publicado en:Mol Ther Oncolytics
Autores principales: Hassan, Faizule, Ni, Shuisong, Arnett, Tyler C., McKell, Melanie C., Kennedy, Michael A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832671/
https://ncbi.nlm.nih.gov/pubmed/29511732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2018.01.002
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