p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:eLife
मुख्य लेखकों: Roy, Sunetra, Tomaszowski, Karl-Heinz, Luzwick, Jessica W, Park, Soyoung, Li, Jun, Murphy, Maureen, Schlacher, Katharina
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: eLife Sciences Publications, Ltd 2018
विषय:
Chromosomes and Gene Expression
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832412/
https://ncbi.nlm.nih.gov/pubmed/29334356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31723
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