Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats

OBJECTIVE: Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degene...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Wang, Weiheng, Wang, Yang, Deng, Guoying, Ma, Jun, Huang, Xiaodong, Yu, Jiangming, Xi, Yanhai, Ye, Xiaojian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832130/
https://ncbi.nlm.nih.gov/pubmed/29535780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7564159
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