Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats

OBJECTIVE: Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degene...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Int
Autori principali: Wang, Weiheng, Wang, Yang, Deng, Guoying, Ma, Jun, Huang, Xiaodong, Yu, Jiangming, Xi, Yanhai, Ye, Xiaojian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832130/
https://ncbi.nlm.nih.gov/pubmed/29535780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/7564159
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