A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

Cancer Associated Fibroblasts (CAFs) promote tumor invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadherin at the CAF membrane and E-cadherin at the cancer...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Labernadie, Anna, Kato, Takuya, Brugués, Agustí, Serra-Picamal, Xavier, Derzsi, Stefanie, Arwert, Esther, Weston, Anne, González-Tarragó, Victor, Elosegui-Artola, Alberto, Albertazzi, Lorenzo, Alcaraz, Jordi, Roca-Cusachs, Pere, Sahai, Erik, Trepat, Xavier
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831988/
https://ncbi.nlm.nih.gov/pubmed/28218910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3478
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