Human beta defensin (HBD) gene copy number affects HBD2 protein levels: impact on cervical bactericidal immunity in pregnancy

Human beta defensin 2 (HBD2) is an endogenous mucosal antimicrobial peptide (AMP) upregulated during infection and inflammation. HBD2 is encoded by the DEFB4 gene, which exhibits extensive copy number variation. Previous studies have demonstrated a relationship between HBD copy number and serum HBD2...

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Библиографические подробности
Опубликовано в: :Eur J Hum Genet
Главные авторы: James, Catherine P., Bajaj-Elliott, Mona, Abujaber, Razan, Forya, Frida, Klein, Nigel, David, Anna L., Hollox, Edward J., Peebles, Donald M.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
Предметы:
Brief Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831986/
https://ncbi.nlm.nih.gov/pubmed/29367706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-017-0061-7
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