Human ADAR1 prevents endogenous RNA from triggering translational shutdown

Type I interferon is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutieres s...

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Pubblicato in:Cell
Autori principali: Chung, Hachung, Calis, Jorg J. A., Wu, Xianfang, Sun, Tony, Yu, Yingpu, Sarbanes, Stephanie L., Dao Thi, Viet Loan, Shilvock, Abigail R., Hoffmann, H.-Heinrich, Rosenberg, Brad R., Rice, Charles M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831367/
https://ncbi.nlm.nih.gov/pubmed/29395325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.038
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