Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms

Human adenosine deaminase acting on RNA 1 (ADAR1) catalyzes adenosine-to-inosine deamination reactions on double-stranded RNA molecules to regulate cellular responses to endogenous and exogenous RNA. Defective ADAR1 editing leads to disorders such as Aicardi-Goutières syndrome, an autoinflammatory d...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sun, Tony, Yu, Yingpu, Wu, Xianfang, Acevedo, Ashley, Luo, Ji-Dung, Wang, Jiayi, Schneider, William M., Hurwitz, Brian, Rosenberg, Brad R., Chung, Hachung, Rice, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000508/
https://ncbi.nlm.nih.gov/pubmed/33723056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021757118
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