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Human ADAR1 prevents endogenous RNA from triggering translational shutdown
Type I interferon is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutieres s...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5831367/ https://ncbi.nlm.nih.gov/pubmed/29395325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.12.038 |
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