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Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-L-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration

Many cobalamin (Cbl)-dependent radical S-adenosyl-L-methionine (SAM) methyltransferases have been identified through sequence alignment and/or genetic analysis; however, few have been studied in vitro. GenK is one such enzyme that catalyzes methylation of the 6′-carbon of gentamicin X(2) (GenX(2)) t...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Kim, Hak Joong, Liu, Yung-nan, McCarty, Reid M., Liu, Hung-wen
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831329/
https://ncbi.nlm.nih.gov/pubmed/29091410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09890
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