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Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-L-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration

Many cobalamin (Cbl)-dependent radical S-adenosyl-L-methionine (SAM) methyltransferases have been identified through sequence alignment and/or genetic analysis; however, few have been studied in vitro. GenK is one such enzyme that catalyzes methylation of the 6′-carbon of gentamicin X(2) (GenX(2)) t...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Kim, Hak Joong, Liu, Yung-nan, McCarty, Reid M., Liu, Hung-wen
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831329/
https://ncbi.nlm.nih.gov/pubmed/29091410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09890
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