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MRE11 promotes tumorigenesis by facilitating resistance to oncogene-induced replication stress

Hypomorphic mutations in the genes encoding the MRE11/RAD50/NBS1 (MRN) DNA repair complex lead to cancer-prone syndromes. MRN binds DNA double strand breaks where it functions in repair and triggers cell cycle checkpoints via activation of the ataxia-telangiectasia mutated (ATM) kinase. To gain unde...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Spehalski, Elizabeth, Capper, Kayla M., Smith, Cheryl J., Morgan, Mary J., Dinkelmann, Maria, Buis, Jeffrey, Sekiguchi, JoAnn M., Ferguson, David O.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831255/
https://ncbi.nlm.nih.gov/pubmed/28819025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1355
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