FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis

The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown. We report the transcriptome analysis of human purified motoneurons, obtained f...

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Publicado en:Stem Cell Reports
Main Authors: De Santis, Riccardo, Santini, Laura, Colantoni, Alessio, Peruzzi, Giovanna, de Turris, Valeria, Alfano, Vincenzo, Bozzoni, Irene, Rosa, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830977/
https://ncbi.nlm.nih.gov/pubmed/28988989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.004
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