Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP

Lower plasma nicotinamide phosphoribosyltransferase (NAMPT) levels are associated with improved response to methotrexate (MTX) in patients with juvenile idiopathic arthritis. Cell-based studies confirmed that reduced cellular NAMPT activity potentiates the pharmacologic activity of MTX; however, the...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Pharmacol Exp Ther
Glavni autori: Singh, Rakesh K., van Haandel, Leon, Heruth, Daniel P., Ye, Shui Q., Leeder, J. Steven, Becker, Mara L., Funk, Ryan S.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
Teme:
Inflammation, Immunopharmacology, and Asthma
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830637/
https://ncbi.nlm.nih.gov/pubmed/29420256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246199
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items