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Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP

Lower plasma nicotinamide phosphoribosyltransferase (NAMPT) levels are associated with improved response to methotrexate (MTX) in patients with juvenile idiopathic arthritis. Cell-based studies confirmed that reduced cellular NAMPT activity potentiates the pharmacologic activity of MTX; however, the...

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Detaylı Bibliyografya
Yayımlandı:J Pharmacol Exp Ther
Asıl Yazarlar: Singh, Rakesh K., van Haandel, Leon, Heruth, Daniel P., Ye, Shui Q., Leeder, J. Steven, Becker, Mara L., Funk, Ryan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830637/
https://ncbi.nlm.nih.gov/pubmed/29420256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246199
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