Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors

We report the design and target validation of chimeric peptide EP45, a novel 45 amino acid monomeric dual agonist peptide that contains amino acid sequence motifs present within the blood glucose-lowering agent exendin-4 (Ex-4) and the appetite-suppressing agent PYY(3–36). In a new high-throughput F...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chepurny, Oleg G., Bonaccorso, Ron L., Leech, Colin A., Wöllert, Torsten, Langford, George M., Schwede, Frank, Roth, Christian L., Doyle, Robert P., Holz, George G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830615/
https://ncbi.nlm.nih.gov/pubmed/29491394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22106-1
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