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Atomic structure of the mitochondrial inner membrane AAA+ protease YME1 reveals the mechanism of substrate processing
We present the first atomic model of a substrate-bound inner mitochondrial membrane AAA+ quality control protease, YME1. Our ~3.4 Å cryo-EM structure reveals how the ATPases form a closed spiral staircase encircling an unfolded substrate, directing it toward the flat, symmetric protease ring. Import...
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| Yayımlandı: | Science |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5829300/ https://ncbi.nlm.nih.gov/pubmed/29097521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao0464 |
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