Immunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy

Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab ve...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sougawa, Nagako, Miyagawa, Shigeru, Fukushima, Satsuki, Kawamura, Ai, Yokoyama, Junya, Ito, Emiko, Harada, Akima, Okimoto, Kaori, Mochizuki-Oda, Noriko, Saito, Atsuhiro, Sawa, Yoshiki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829260/
https://ncbi.nlm.nih.gov/pubmed/29487310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21923-8
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