Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion from pancreatic beta cells and suppresses glucagon secretion from alpha cells. It remains controversial, however, whether GLP-1 receptor (GLP-1R) is expressed in mature alpha cells. In this study, unlike previous studies using non-diabetic...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Nakashima, Koji, Kaneto, Hideaki, Shimoda, Masashi, Kimura, Tomohiko, Kaku, Kohei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829082/
https://ncbi.nlm.nih.gov/pubmed/29487355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21751-w
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