Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes

Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofib...

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Publicado en:Clin Pharmacol Ther
Autores principales: Rotroff, Daniel M., Pijut, Sonja S., Marvel, Skylar W., Jack, John R., Havener, Tammy M., Pujol, Aurora, Schluter, Agatha, Graf, Gregory A., Ginsberg, Henry N., Shah, Hetal S., Gao, He, Morieri, Mario-Luca, Doria, Alessandro, Mychaleckyi, Josyf C., McLeod, Howard L., Buse, John B., Wagner, Michael J., Motsinger-Reif, Alison A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828950/
https://ncbi.nlm.nih.gov/pubmed/28736931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.798
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