PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid

The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the presence of atherogenic dyslipidemia. We investigated whether genetic variability in the PPARA gene, coding for the pharmacological target of fibrates (PPAR-α), could be used to improve the selection of...

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發表在:Diabetes
Main Authors: Morieri, Mario Luca, Shah, Hetal S., Sjaarda, Jennifer, Lenzini, Petra A., Campbell, Hannah, Motsinger-Reif, Alison A., Gao, He, Lovato, Laura, Prudente, Sabrina, Pandolfi, Assunta, Pezzolesi, Marcus G., Sigal, Ronald J., Paré, Guillaume, Marcovina, Santica M., Rotroff, Daniel M., Patorno, Elisabetta, Mercuri, Luana, Trischitta, Vincenzo, Chew, Emily Y., Kraft, Peter, Buse, John B., Wagner, Michael J., Cresci, Sharon, Gerstein, Hertzel C., Ginsberg, Henry N., Mychaleckyj, Josyf C., Doria, Alessandro
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2020
主題:
Genetics/Genomes/Proteomics/Metabolomics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085251/
https://ncbi.nlm.nih.gov/pubmed/31974142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0973
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