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Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neutralizing antibodies (bnAbs) have been reported to...

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Publicat a:eLife
Autors principals: Ovchinnikov, Victor, Louveau, Joy E, Barton, John P, Karplus, Martin, Chakraborty, Arup K
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828663/
https://ncbi.nlm.nih.gov/pubmed/29442996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33038
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