Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unknown. Here, we show that lipoylation of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (αKDH) complexes is a dynamically regulated proces...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Paredes, Felipe, Sheldon, Kely, Lassègue, Bernard, Williams, Holly C., Faidley, Elizabeth A., Benavides, Gloria A., Torres, Gloria, Sanhueza-Olivares, Fernanda, Yeligar, Samantha M., Griendling, Kathy K., Darley-Usmar, Victor, San Martin, Alejandra
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828627/
https://ncbi.nlm.nih.gov/pubmed/29434038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720693115
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