Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unknown. Here, we show that lipoylation of the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (αKDH) complexes is a dynamically regulated proces...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Paredes, Felipe, Sheldon, Kely, Lassègue, Bernard, Williams, Holly C., Faidley, Elizabeth A., Benavides, Gloria A., Torres, Gloria, Sanhueza-Olivares, Fernanda, Yeligar, Samantha M., Griendling, Kathy K., Darley-Usmar, Victor, San Martin, Alejandra
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828627/
https://ncbi.nlm.nih.gov/pubmed/29434038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720693115
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