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Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm

Cysteinyl-leukotrienes (cys-LTs) are 5-lipoxygenase-derived lipid mediators involved in the pathogenesis and progression of inflammatory disorders, in particular asthma. We have previously found evidence linking these mediators to increased levels of proteolytic enzymes in tissue specimens of human...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Di Gennaro, Antonio, Araújo, Ana Carolina, Busch, Albert, Jin, Hong, Wågsäter, Dick, Vorkapic, Emina, Caidahl, Kenneth, Eriksson, Per, Samuelsson, Bengt, Maegdefessel, Lars, Haeggström, Jesper Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828611/
https://ncbi.nlm.nih.gov/pubmed/29432192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717906115
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