SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Progressive failure of insulin-producing β-cells is the central event leading to diabetes, but the signaling networks controlling β-cell fate remain poorly understood. Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility gene GLIS3, has a major role in maintaining the...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Juan-Mateu, Jonàs, Alvelos, Maria Inês, Turatsinze, Jean-Valéry, Villate, Olatz, Lizarraga-Mollinedo, Esther, Grieco, Fabio Arturo, Marroquí, Laura, Bugliani, Marco, Marchetti, Piero, Eizirik, Décio L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2018
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828453/
https://ncbi.nlm.nih.gov/pubmed/29246973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0736
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